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PMID: 21584795 Published · ppublish English Journal Article

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine ·Vol. 32 ·No. 4 ·2011-08-00 ·Pages 787-99

Koo JS, Park S, Kim SI, Lee S, Park BW

Abstract

We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.

MeSH Terms
Adult Biomarkers, Tumor/analysis,metabolism Breast Neoplasms/metabolism,mortality,pathology Carcinoma, Ductal, Breast/metabolism,mortality,pathology Carcinoma, Intraductal, Noninfiltrating/metabolism,mortality,pathology Caveolin 1/biosynthesis Caveolins/biosynthesis Disease Progression Female Humans Immunohistochemistry Kaplan-Meier Estimate Middle Aged Neoplasm Staging Platelet-Derived Growth Factor/biosynthesis Prognosis Tissue Array Analysis Tumor Microenvironment/physiology
Chemicals
Biomarkers, Tumor Caveolin 1 Caveolins Platelet-Derived Growth Factor
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Koo Ja Seung
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Park Seho
Kim Seung Il
Lee Sarah
Park Byeong-Woo
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28 references, click to expand
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Article Info
Journal
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Abbr.
Tumour Biol
ISSN
1423-0380
DOI
10.1007/s13277-011-0181-6
Published
2011-08-00
Epub
2011-00-17
Pages
787-99
Language
English
Region
Netherlands
NLM ID
8409922
Subset
IM
External Links
PubMed source DOI: 10.1007/s13277-011-0181-6
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