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题目:: Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis.
作者:: Zhang(Lei),Li(Jian-Min),Liu(Xin-Guang),Ma(Dao-Xin),Hu(Nai-Wen),Li(Yong-Gang),Li(Wei),Hu(Yu),Yu(Shuang),Qu(Xun),Yang(Mei-Xiang),Feng(A-Lei),Wang(Guang-Hui)
状态:: 发布时间2011-08-15 , 更新时间 2011-08-15
期刊:: J Clin Immunol
摘要:: T-helper (Th) 22 and Th17 cells are implicated in the pathogenesis of autoimmune diseases. The roles of Th22 cells in the pathophysiology of rheumatoid arthritis (RA) remain unsettled.,CD4(+)IFNγ(-)IL17(-)IL-22(+) T cells (Th22 cells), CD4(+)IFNγ(-)IL-22(-)IL17(+) T cells (pure Th17 cells), CD4(+)IL17(+) T cells (Th17 cells), and CD4(+)IFNγ(+) T cells (Th1 cells) in RA, osteoarthritis patients, and healthy controls were examined by flow cytometry. Plasma IL-22 and IL-17 levels were examined by enzyme-linked immunosorbent assay.,Th22 cells, pure Th17 cells, Th17 cells, and interleukin-22 were significantly elevated in RA patients compared with osteoarthritis and healthy controls, but there were no significant differences regarding Th1 cells and interleukin-17. Th22 cells showed a positive correlation with interleukin-22 as well as pure Th17 cells or Th17 cells in RA patients. Additionally, the percentages of Th22 cells, pure Th17 cells as well as Th17 cells correlated positively with both C-reactive protein levels and 28-joints disease activity score.,Together, our results indicated a possible role of Th22 pure Th17 cells and Th17 cells in RA, and blockade of the interleukin-22 may be a reasonable therapeutic strategy for RA.
语言:: eng
DOI:: 10.1007/s10875-011-9540-8

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