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PMID: 2154725 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP.

Neuroscience letters ·Vol. 108 ·No. 3 ·1990-01-22 ·Pages 261-6

Bashir ZI, Tam B, Collingridge GL

Abstract

The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-D-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2(+)-free medium and the induction of long-term potentiation (LTP) in Mg2(+)-containing medium. Both of these effects were reversed by D-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor.

MeSH Terms

Action Potentials/drug effects Animals Glycine/metabolism,physiology Hippocampus/drug effects,metabolism,physiology Kynurenic Acid/analogs & derivatives,pharmacology Neuronal Plasticity/drug effects Rats Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/antagonists & inhibitors,physiology Synaptic Transmission/drug effects

Chemicals

Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter Kynurenic Acid 7-chlorokynurenic acid Glycine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bashir Z I

Department of Pharmacology, School of Medical Sciences, University of Bristol, U.K.

Tam B

Collingridge G L

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(90)90651-o

Published

1990-01-22

Pages

261-6

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(90)90651-o View journal details

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Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP.

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