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PMID: 21546911 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Wolbachia and the biological control of mosquito-borne disease.

EMBO reports ·Vol. 12 ·No. 6 ·2011-06-00 ·Pages 508-18

Iturbe-Ormaetxe I, Walker T, O' Neill SL

Abstract

Mosquito-borne diseases such as malaria, dengue fever and filariasis cause an enormous health burden to people living in tropical and subtropical regions of the world. Despite years of intense effort to control them, many of these diseases are increasing in prevalence, geographical distribution and severity, and options to control them are limited. The transinfection of mosquitos with the maternally inherited, endosymbiotic bacteria Wolbachia is a promising new biocontrol approach. Fruit fly Wolbachia strains can invade and sustain themselves in mosquito populations, reduce adult lifespan, affect mosquito reproduction and interfere with pathogen replication. Wolbachia-infected Aedes aegypti mosquitoes have been released in areas of Australia in which outbreaks of dengue fever occur, as a prelude to the application of this technology in dengue-endemic areas of south-east Asia.

MeSH Terms
Animals Australia Culicidae/microbiology Dengue/prevention & control,transmission Genetic Fitness Insect Vectors/microbiology Malaria/prevention & control,transmission Mosquito Control Wolbachia/genetics,physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Iturbe-Ormaetxe Iñaki
School of Biological Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia.
Walker Thomas
O' Neill Scott L
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-3178
DOI
10.1038/embor.2011.84
Published
2011-06-00
Epub
2011-00-06
Pages
508-18
Language
English
Region
England
NLM ID
100963049
PMCID
PMC3128286
Subset
IM
External Links
PubMed source DOI: 10.1038/embor.2011.84 PMC Full Text View journal details
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