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题目:: Generation of cell-mediated cytotoxicity against bovine-papilloma-virus-transformed primary mouse cell lines.
作者:: Laatikainen(A),Karjalainen(H),Sarkkinen(H),Syrjänen(K),Mäntyjärvi(R)
状态:: 发布时间1990-03-20 , 更新时间 2006-11-15
期刊:: Cancer Immunol Immunother
摘要:: The immunogenicity and immunosensitivity of primary mouse cell lines transformed by bovine papilloma virus 1 (BPV1) DNA were studied in a syngeneic mouse model by determining cell-mediated cytotoxicity in the spleens of mice immunized with the transformed cells. One of the cell lines induced the generation of cell-line-specific Thy1.2-positive cytotoxic effector cells. However, most of the cell lines tested induced the generation of Thy1.2-positive effector cells, which in addition to BPV1-transformed cells were able to lyse a syngeneic cell line transformed by methylcholanthrene. The lysis of BPV1- and methylcholanthrene-transformed cell lines was mediated by recognition of the same antigenic determinants expressed on these cells, and all the BPV1-transformed cell lines were sensitive to lysis by these nonspecific effector cells of the lymphokine-activated killer (LAK) type.
语言:: eng
DOI:

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