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PMID: 21543223 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The cancerous translation apparatus.

Current opinion in genetics & development ·Vol. 21 ·No. 4 ·2011-08-00 ·Pages 474-83

Stumpf CR, Ruggero D

Abstract

Deregulations in translational control are critical features of cancer initiation and progression. Activation of key oncogenic pathways promotes rapid and dramatic translational reprogramming, not simply by increasing overall protein synthesis, but also by modulating specific mRNA networks that promote cellular transformation. Additionally, ribosomopathies caused by mutations in ribosome components alter translational regulation leading to specific pathological features, including cancer susceptibility. Exciting advances in our understanding of translational control in cancer have illuminated a striking specificity innate to the translational apparatus. Characterizing this specificity will provide novel insights into how cells normally utilize translational control to modulate gene expression, how it is deregulated in cancer, and how these processes can be targeted to develop new cancer therapies.

MeSH Terms
Animals Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Neoplasms/genetics,metabolism,pathology Protein Biosynthesis RNA, Messenger/genetics,metabolism Signal Transduction
Chemicals
RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stumpf Craig R
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158-3110, USA.
Ruggero Davide
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Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
1879-0380
DOI
10.1016/j.gde.2011.03.007
Published
2011-08-00
Epub
2011-00-03
Pages
474-83
Language
English
Region
England
NLM ID
9111375
PMCID
PMC3481834
Subset
IM
Grants
NCI NIH HHS · R01 CA140456 · United States
NCI NIH HHS · R01 CA154916 · United States
NIDDK NIH HHS · R01 DK098057 · United States
NHLBI NIH HHS · R01 HL085572 · United States
External Links
PubMed source DOI: 10.1016/j.gde.2011.03.007 PMC Full Text View journal details
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