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PMID: 2153219 Published · ppublish English Journal Article

Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus.

Journal of virology ·Vol. 64 ·No. 2 ·1990-02-00 ·Pages 493-8

Buller RS, Wehrly K, Portis JL, Chesebro B

Abstract

Infection of certain strains of mice with the ecotropic Friend murine leukemia virus results in the generation of recombinant polytropic mink cell focus-inducing viruses and the development of erythroleukemia. We isolated a Friend mink cell focus-inducing virus (F-MCF-98D) from a Friend murine leukemia virus-infected BALB/c mouse which caused primarily a neurological disease as well as a low incidence of leukemia in susceptible IRW mice. Through genetic studies with the resistant C57BL/10 strain, we identified two genes which correlated with restricted viral replication and resistance to the development of disease caused by F-MCF-98D. One gene correlated with the expression of an endogenous gp70 linked to the Rmcf gene and might act by viral interference. The mechanism of action of the second gene was less clear, but it appeared to be associated with development of an antiviral antibody response.

MeSH Terms
Animals Antibodies, Viral/analysis Antibody Formation Cells, Cultured Central Nervous System Diseases/immunology,microbiology Crosses, Genetic Friend murine leukemia virus/genetics,immunology,physiology Immunity, Innate Leukemia Virus, Murine/genetics Leukemia, Experimental/immunology,microbiology Mice Mice, Inbred BALB C Mice, Inbred Strains Mink Cell Focus-Inducing Viruses/genetics,immunology,physiology Species Specificity Virus Replication
Chemicals
Antibodies, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Buller R S
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840.
Wehrly K
Portis J L
Chesebro B
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.2.493-498.1990
Published
1990-02-00
Pages
493-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249136
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.64.2.493-498.1990 PMC Full Text View journal details
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