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题目:: Persistence of memory B cells in mice deprived of T cell help.
作者:: Vieira(P),Rajewsky(K)
状态:: 发布时间1991-05-23 , 更新时间 2006-11-15
期刊:: Int Immunol
摘要:: The influence of T cell help on the induction, maintenance, and recall of B cell memory to a T cell-dependent antigen was studied in mice. The antigen was a hapten coupled to a protein carrier, and helper T cells were eliminated before, during, or after immunization by treatment of the animals with anti-CD4 antibodies. B cell memory was quantified in an adoptive cell transfer system, transferring B cells from the primed animals together with carrier-primed syngeneic T cells. Anti-CD4 treatment completely inhibited the induction of primary and secondary responses and of B cell memory. In contrast, it did not affect established B cell memory over a period of at least 6 weeks. Consequently, this suggests that within this time range B cell memory to a T cell-dependent antigen does not rely on the continuous recruitment of naive B cells into the memory compartment, and memory B cells need little or no (antigen-mediated) T cell help in order to persist.
语言:: eng
DOI:

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