A model of the mechanisms of long-term potentiation in the hippocampus.

Biological cybernetics ·Vol. 64 ·No. 1 ·1990-00-00 ·Pages 33-9

Kitajima T, Hara K

Abstract

Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the NMDA-receptor channel, protein phosphorylation and protein turnover. The validity of the model is discussed based on the results of computer simulations.

MeSH Terms

Animals Calcium/metabolism Computer Simulation Cybernetics Electric Stimulation Electrophysiology Hippocampus/physiology Models, Neurological Protein Kinases/metabolism Receptors, N-Methyl-D-Aspartate/metabolism

Chemicals

Receptors, N-Methyl-D-Aspartate Protein Kinases Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kitajima T

Faculty of Engineering, Yamagata University, Japan.

Hara K

References (19)

19 references, click to expand

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Article Info

Journal

Biological cybernetics

Abbr.

Biol Cybern

ISSN

0340-1200

DOI

10.1007/BF00203628

Published

1990-00-00

Pages

33-9

Language

English

Region

Germany

NLM ID

7502533

Subset

External Links

PubMed source DOI: 10.1007/BF00203628 View journal details

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A model of the mechanisms of long-term potentiation in the hippocampus.

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