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PMID: 21458666 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic interactions in cancer progression and treatment.

Cell ·Vol. 145 ·No. 1 ·2011-04-01 ·Pages 30-8

Ashworth A, Lord CJ, Reis-Filho JS

Abstract

As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.

MeSH Terms
Animals Disease Progression Epistasis, Genetic Humans Mutation Neoplasms/genetics,physiopathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ashworth Alan
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. alan.ashworth@icr.ac.uk
Lord Christopher J
Reis-Filho Jorge S
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2011.03.020
Email
alan.ashworth@icr.ac.uk
Published
2011-04-01
Pages
30-8
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Grants
Breast Cancer Now · BREAST CANCER NOW RESEARCH CENTRE · United Kingdom
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.1016/j.cell.2011.03.020 View journal details
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