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PMID: 21457530 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Abnormalities of T cell signaling in systemic lupus erythematosus.

Arthritis research & therapy ·Vol. 13 ·No. 2 ·2011-03-17 ·Pages 207

Moulton VR, Tsokos GC

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production, contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy.

MeSH Terms
Humans Lupus Erythematosus, Systemic/genetics,immunology Signal Transduction/genetics,immunology T-Lymphocytes/immunology Transcription, Genetic/genetics,immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moulton Vaishali R
Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. vmoulton@bidmc.harvard.edu
Tsokos George C
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Article Info
Journal
Arthritis research & therapy
Abbr.
Arthritis Res Ther
ISSN
1478-6362
Published
2011-03-17
Epub
2011-00-17
Pages
207
Language
English
Region
England
NLM ID
101154438
PMCID
PMC3132009
Subset
IM
Grants
NIAID NIH HHS · R01 AI042269 · United States
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