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PMID: 21450447 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Nuclear organization: taking a position on gene expression.

Current opinion in cell biology ·Vol. 23 ·No. 3 ·2011-06-00 ·Pages 354-9

Geyer PK, Vitalini MW, Wallrath LL

Abstract

Eukaryotic genomes are divided into chromosomes that occupy defined regions or territories within the nucleus. These chromosome territories (CTs) are arranged based on the transcriptional activity and chromatin landscape of domains. In general, transcriptionally silent domains reside at the nuclear periphery, whereas active domains locate within the interior. Changes in nuclear position are observed for stress-induced and developmentally regulated tissue-specific genes. Upon activation, these genes move away from a CT to inter-chromosomal space containing nuclear bodies enriched in gene expression machinery. Gene activation is not always accompanied by movement, as positioning is dictated by many determinants, including gene structure and the local genomic environment. Collectively, tissue-specific nuclear organization results from a culmination of inputs that result in proper transcriptional regulation.

MeSH Terms
Animals Cell Nucleus/chemistry,genetics Chromatin/metabolism Chromosomes Gene Expression Regulation Humans Transcriptional Activation
Chemicals
Chromatin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Geyer Pamela K
University of Iowa, Iowa City, IA 52242, United States.
Vitalini Michael W
Wallrath Lori L
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2011.03.002
Published
2011-06-00
Epub
2011-00-28
Pages
354-9
Language
English
Region
England
NLM ID
8913428
PMCID
PMC4160055
Subset
IM
Grants
NIGMS NIH HHS · GM061513 · United States
NIGMS NIH HHS · R01 GM087341 · United States
NIGMS NIH HHS · R01 GM061513 · United States
NIGMS NIH HHS · GM087341 · United States
NIGMS NIH HHS · R01 GM042539 · United States
NIAMS NIH HHS · AR060012 · United States
NIGMS NIH HHS · F32 GM085974 · United States
NIAMS NIH HHS · R21 AR060012 · United States
NIGMS NIH HHS · GM085974 · United States
NIGMS NIH HHS · GM042539 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2011.03.002 PMC Full Text View journal details
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