| GeneLibs

题目:: β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.
作者:: Josson(Sajni),Nomura(Takeo),Lin(Jen-Tai),Huang(Wen-Chin),Wu(Daqing),Zhau(Haiyen E),Zayzafoon(Majd),Weizmann(M Neale),Gururajan(Murali),Chung(Leland W K)
状态:: 发布时间2011-04-04 , 更新时间 2016-11-25
期刊:: Cancer Res
摘要:: Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. β2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. β2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells. Inhibition of either β2-M or HFE results in reversion of EMT. These results demonstrate the role of β2-M in cancer metastasis and lethality. Thus, β2-M and its downstream signaling pathways are promising prognostic markers of cancer metastases and novel therapeutic targets for cancer therapy.
语言:: eng
DOI:

文献库文献相关信息