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PMID: 2138990 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli.

FEMS microbiology letters ·Vol. 54 ·No. 1-3 ·1990-01-01 ·Pages 129-33

Mengin-Lecreulx D, van Heijenoort J

Abstract

It was speculated that the increase of the UDP-GlcNAc pool observed with chloramphenicol can modulate the residual PEP:UDP-GlcNAc-enolpyruvate activity of fosfomycin-treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP-MurNAc-pentapeptide to sustain peptidoglycan synthesis at a rate that will antagonize fosfomycin-induced lysis.

MeSH Terms

Bacteriolysis/drug effects Chloramphenicol/pharmacology Escherichia coli/drug effects,metabolism Fosfomycin/pharmacology Glucosyltransferases/antagonists & inhibitors N-Acetylglucosaminyltransferases Nucleotides/biosynthesis Peptidoglycan/biosynthesis

Chemicals

Nucleotides Peptidoglycan Fosfomycin Chloramphenicol Glucosyltransferases N-Acetylglucosaminyltransferases PEP-UDP-GlcNAc transferase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mengin-Lecreulx D

Unité Associée du CNRS, Biochimie Moléculaire et Cellulaire, Université Paris-Sud, Orsay, France.

van Heijenoort J

Article Info

Journal

FEMS microbiology letters

Abbr.

FEMS Microbiol Lett

ISSN

0378-1097

DOI

10.1016/0378-1097(90)90270-z

Published

1990-01-01

Pages

129-33

Language

English

Region

England

NLM ID

7705721

Subset

External Links

PubMed source DOI: 10.1016/0378-1097(90)90270-z View journal details

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Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli.

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