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PMID: 21383745 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression.

Nature medicine ·Vol. 17 ·No. 3 ·2011-03-00 ·Pages 320-9

Bissell MJ, Hines WC

Abstract

Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.

MeSH Terms
Disease Progression Homeostasis Humans Neoplasms/physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bissell Mina J
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. mjbissell@lbl.gov
Hines William C
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.2328
Email
mjbissell@lbl.gov
Published
2011-03-00
Pages
320-9
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC3569482
Subset
IM
Grants
NCI NIH HHS · R37 CA064786 · United States
NCI NIH HHS · U54 CA143836 · United States
NCI NIH HHS · U54CA143836 · United States
NCI NIH HHS · U54 CA126552 · United States
NCI NIH HHS · R37CA064786 · United States
NCI NIH HHS · U54 CA112970 · United States
NCI NIH HHS · U01CA143233 · United States
NCI NIH HHS · R01 CA057621 · United States
NCI NIH HHS · R01CA057621 · United States
NCI NIH HHS · U01 CA143233 · United States
NCI NIH HHS · R01 CA064786 · United States
NCI NIH HHS · U54CA126552 · United States
NCI NIH HHS · U54CA112970 · United States
External Links
PubMed source DOI: 10.1038/nm.2328 PMC Full Text View journal details
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