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PMID: 21383074 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

On emerging nuclear order.

The Journal of cell biology ·Vol. 192 ·No. 5 ·2011-03-07 ·Pages 711-21

Rajapakse I, Groudine M

Abstract

Although the nonrandom nature of interphase chromosome arrangement is widely accepted, how nuclear organization relates to genomic function remains unclear. Nuclear subcompartments may play a role by offering rich microenvironments that regulate chromatin state and ensure optimal transcriptional efficiency. Technological advances now provide genome-wide and four-dimensional analyses, permitting global characterizations of nuclear order. These approaches will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease.

MeSH Terms
Animals Cell Nucleus/ultrastructure Chromatin Assembly and Disassembly Chromosomes/physiology,ultrastructure Gene Expression Regulation Gene Regulatory Networks Humans Interphase Intranuclear Space/ultrastructure Models, Genetic Neoplasms/genetics Translocation, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rajapakse Indika
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Groudine Mark
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.201010129
Published
2011-03-07
Pages
711-21
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC3051810
Subset
IM
Grants
NIDDK NIH HHS · R37 DK044746 · United States
NIDDK NIH HHS · K25DK082791-01A109 · United States
NIDDK NIH HHS · K25 DK082791 · United States
NIDDK NIH HHS · R37 DK44746 · United States
NHLBI NIH HHS · R01 HL65440 · United States
NHLBI NIH HHS · R01 HL065440 · United States
External Links
PubMed source DOI: 10.1083/jcb.201010129 PMC Full Text View journal details
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