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PMID: 21370347 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.

Angewandte Chemie (International ed. in English) ·Vol. 50 ·No. 11 ·2011-03-07 ·Pages 2606-9

Tercel M, Atwell GJ, Yang S, Ashoorzadeh A, Stevenson RJ, Botting KJ, Gu Y, Mehta SY, Denny WA, Wilson WR, Pruijn FB

Abstract

暂无摘要

MeSH Terms

Amines/chemistry,pharmacology Animals Antineoplastic Agents/chemistry,pharmacology Cell Line, Tumor Cell Survival/drug effects Duocarmycins Humans Hypoxia Indoles/chemistry,pharmacology Mice Molecular Structure Prodrugs/chemistry Pyrrolidinones/chemistry,pharmacology

Chemicals

Amines Antineoplastic Agents Duocarmycins Indoles Prodrugs Pyrrolidinones duocarmycin A

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Tercel Moana

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. m.tercel@auckland.ac.nz

Atwell Graham J

Yang Shangjin

Ashoorzadeh Amir

Stevenson Ralph J

Botting K Jane

Gu Yongchuan

Mehta Sunali Y

Denny William A

Wilson William R

Pruijn Frederik B

Article Info

Journal

Angewandte Chemie (International ed. in English)

Abbr.

Angew Chem Int Ed Engl

ISSN

1521-3773

DOI

10.1002/anie.201004456

m.tercel@auckland.ac.nz

Published

2011-03-07

Epub

2011-00-17

Pages

2606-9

Language

English

Region

Germany

NLM ID

0370543

Subset

External Links

PubMed source DOI: 10.1002/anie.201004456 View journal details

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Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.

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