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PMID: 21360287 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.

Current osteoporosis reports ·Vol. 9 ·No. 2 ·2011-06-00 ·Pages 46-52

Rankin EB, Giaccia AJ, Schipani E

Abstract

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the cellular response to hypoxia by regulating the expression of genes controlling metabolic adaptation, oxygen delivery, and survival in response to oxygen deprivation. Recent studies have identified an important role for HIF-1 and HIF-2 in the regulation of skeletal development, bone formation, and regeneration, as well as joint formation and homeostasis. In addition, overexpression of HIF-1 and HIF-2 is clinically associated with osteosarcoma and osteoarthritis. Together, these findings implicate hypoxic signaling as a central regulator of bone biology and disease.

MeSH Terms
Bone and Bones/physiopathology Cartilage Cell Hypoxia/genetics,physiology Hematopoiesis Humans Hypoxia/physiopathology Hypoxia-Inducible Factor 1/genetics,metabolism Osteogenesis/physiology Oxygen/metabolism
Chemicals
Hypoxia-Inducible Factor 1 Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rankin Erinn B
Endocrine Unit, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA.
Giaccia Amato J
Schipani Ernestina
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Article Info
Journal
Current osteoporosis reports
Abbr.
Curr Osteoporos Rep
ISSN
1544-2241
DOI
10.1007/s11914-011-0047-2
Published
2011-06-00
Pages
46-52
Language
English
Region
United States
NLM ID
101176492
PMCID
PMC4012534
Subset
IM
Grants
NIAMS NIH HHS · R01 AR048191 · United States
NIAMS NIH HHS · R01 AR048191-06 · United States
External Links
PubMed source DOI: 10.1007/s11914-011-0047-2 PMC Full Text View journal details
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