Resistance to BRAF inhibition in melanomas.

Drug Resistance, Neoplasm Enzyme Activation/drug effects Gene Expression Regulation, Neoplastic Humans Indoles/pharmacology,therapeutic use MAP Kinase Signaling System/drug effects Melanoma/drug therapy,enzymology,genetics Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors Mutation Proto-Oncogene Proteins B-raf/antagonists & inhibitors,genetics Sulfonamides/pharmacology,therapeutic use Vemurafenib

Indoles Sulfonamides Vemurafenib BRAF protein, human Proto-Oncogene Proteins B-raf Mitogen-Activated Protein Kinase Kinases