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题目:: Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature.
作者:: Galindo(Cristi L),McIver(Lauren J),Tae(Hongseok),McCormick(John F),Skinner(Michael A),Hoeschele(Ina),Lewis(Cheryl M),Minna(John D),Boothman(David A),Garner(Harold R)
状态:: 发布时间2011-02-14 , 更新时间 2016-11-22
期刊:: Genes Chromosomes Cancer
摘要:: Using a custom CGH-like oligonucleotide array to measure the global microsatellite content in the genomes of 72 cancer, cancer-free, and high risk patient and cell line samples (56 germline DNA and 16 in tumor or tumor cell line DNA) we found a unique, reproducible, and statistically significant pattern of 18 motif-specific microsatellite families (out of 962 possible 1-6 mer repeats) in breast cancer patient germline and tumor DNA, but not in germline DNA of cancer-free volunteer controls or in breast cancer patients with BRCA1/2 mutations. These high-similarity A/T rich repetitive motifs were also more pronounced in the germlines and tumors of colon cancer tumor patients (3/6 samples) and microsatellite unstable colon cancer cell lines; however, germline DNA of sporadic breast cancer patients exhibited the largest global content shift for those motifs with extreme AT/GC ratios. These results indicate that global microsatellite variability is complex, suggest the existence of a previously unknown genomic destabilization mechanism in breast cancer patients' germline DNA, and warrant further testing of such microsatellite variability as a predictor of future breast cancer development.
语言:: eng
DOI:

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