Home LiteratureArticle Details
PMID: 21317179 Published · ppublish English Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer.

Thorax ·Vol. 66 ·No. 4 ·2011-04-00 ·Pages 308-13

Baldwin DR, Duffy SW, Wald NJ, Page R, Hansell DM, Field JK

Abstract

The UK Lung Screen (UKLS) is a randomised controlled trial of the use of low-dose multidetector CT for lung cancer screening. It completed the Health Technology Appraisal (HTA)-funded feasibility stage in October 2009 and the pilot UKLS will be initiated in early 2011. The pilot will randomise 4000 subjects to either low-dose CT screening or no screening. The full study, due to start in September 2012, if progression criteria are met, will randomise a further 28,000 subjects from seven centres in the UK. Subjects will be selected if they have sufficient risk of developing lung cancer according to the Liverpool Lung Project risk model. The UKLS employs the 'Wald Single Screen Design', which was modelled in the UKLS feasibility study. This paper describes the modelling of nodule management in UKLS by using volumetric analysis with a single initial screen design and follow-up period of 10 years. This modelling has resulted in the development and adoption of the UKLS care pathway, which will be implemented in the planned CT screening trial in the UK.

MeSH Terms
Aged Clinical Protocols Critical Pathways/organization & administration Disease Progression Early Detection of Cancer/methods Humans Lung Neoplasms/diagnostic imaging,pathology,therapy Middle Aged Multicenter Studies as Topic/methods Patient Care Team Patient Selection Radiation Dosage Randomized Controlled Trials as Topic/methods Research Design Time Factors Tomography, X-Ray Computed/methods
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Baldwin D R
Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals, City Campus, Hucknall Road, Nottingham NG5 1PB, UK. david.baldwin@nuh.nhs.uk
Duffy S W
Wald N J
Page R
Hansell D M
Field J K
References (25)
25 references, click to expand
  1. The LLP risk model: an individual risk prediction model for lung cancer.
    Br J Cancer. 2008 Jan 29;98(2):270-6 PMID: 18087271
  2. Could CT screening for lung cancer ever be cost effective in the United Kingdom?
    Cost Eff Resour Alloc. 2008 Feb 26;6:5 PMID: 18302756
  3. Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON).
    Br J Cancer. 2010 Jan 5;102(1):27-34 PMID: 19935789
  4. The Danish randomized lung cancer CT screening trial--overall design and results of the prevalence round.
    J Thorac Oncol. 2009 May;4(5):608-14 PMID: 19357536
  5. A risk model for prediction of lung cancer.
    J Natl Cancer Inst. 2007 May 2;99(9):715-26 PMID: 17470739
  6. Clinical practice. Lung cancer screening.
    N Engl J Med. 2005 Jun 30;352(26):2714-20 PMID: 15987920
  7. Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR).
    Lung Cancer. 2007 Oct;58(1):50-8 PMID: 17624475
  8. Lung cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
    J Natl Cancer Inst. 2010 May 19;102(10):722-31 PMID: 20442215
  9. Cumulative incidence of false-positive results in repeated, multimodal cancer screening.
    Ann Fam Med. 2009 May-Jun;7(3):212-22 PMID: 19433838
  10. Management of lung nodules detected by volume CT scanning.
    N Engl J Med. 2009 Dec 3;361(23):2221-9 PMID: 19955524
  11. Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers.
    Radiology. 2007 Feb;242(2):555-62 PMID: 17255425
  12. The Liverpool Lung Project research protocol.
    Int J Oncol. 2005 Dec;27(6):1633-45 PMID: 16273220
  13. Earlier diagnosis and survival in lung cancer.
    Br Med J. 1969 Nov 1;4(5678):260-2 PMID: 5345935
  14. Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer.
    Lung Cancer. 2005 Jan;47(1):9-15 PMID: 15603850
  15. Maximising benefit and minimising harm of screening.
    BMJ. 2008 Mar 1;336(7642):480-3 PMID: 18310003
  16. Variations in lung cancer risk among smokers.
    J Natl Cancer Inst. 2003 Mar 19;95(6):470-8 PMID: 12644540
  17. Lung cancer screening: the way forward.
    Br J Cancer. 2008 Aug 19;99(4):557-62 PMID: 18665179
  18. Overdiagnosis in chest radiographic screening for lung carcinoma: frequency.
    Cancer. 2003 Mar 1;97(5):1271-5 PMID: 12599235
  19. The National Lung Screening Trial: overview and study design.
    Radiology. 2011 Jan;258(1):243-53 PMID: 21045183
  20. Design, recruitment and baseline results of the ITALUNG trial for lung cancer screening with low-dose CT.
    Lung Cancer. 2009 Apr;64(1):34-40 PMID: 18723240
  21. Survival of patients with stage I lung cancer detected on CT screening.
    N Engl J Med. 2006 Oct 26;355(17):1763-71 PMID: 17065637
  22. Is late diagnosis of lung cancer inevitable? Interview study of patients' recollections of symptoms before diagnosis.
    Thorax. 2005 Apr;60(4):314-9 PMID: 15790987
  23. A randomized study of lung cancer screening with spiral computed tomography: three-year results from the DANTE trial.
    Am J Respir Crit Care Med. 2009 Sep 1;180(5):445-53 PMID: 19520905
  24. Lung cancer screening by spiral CT. What is the optimal target population for screening trials?
    Lung Cancer. 2002 Dec;38(3):243-52 PMID: 12445745
  25. Nodule management protocol of the NELSON randomised lung cancer screening trial.
    Lung Cancer. 2006 Nov;54(2):177-84 PMID: 16989922
Article Info
Journal
Thorax
Abbr.
Thorax
ISSN
1468-3296
DOI
10.1136/thx.2010.152066
Email
david.baldwin@nuh.nhs.uk
Published
2011-04-00
Epub
2011-00-11
Pages
308-13
Language
English
Region
England
NLM ID
0417353
PMCID
PMC3063456
Subset
IM
Grants
Department of Health · 07/82/01 · United Kingdom
Department of Health · 09/61/01 · United Kingdom
Department of Health · HTA/09/61/01 · United Kingdom
External Links
PubMed source DOI: 10.1136/thx.2010.152066 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2