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题目:: Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.
作者:: Soderquest(Katrina),Walzer(Thierry),Zafirova(Biljana),Klavinskis(Linda S),Polić(Bojan),Vivier(Eric),Lord(Graham M),Martín-Fontecha(Alfonso)
状态:: 发布时间2011-03-03 , 更新时间 2016-11-22
期刊:: J Immunol
摘要:: It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8(+) T cell fate by killing recently activated CD8(+) T cells in an NKG2D- and perforin-dependent manner. In the absence of NK cells, the differentiation of CD8(+) T cells is strongly biased toward a central memory T cell phenotype. Although, on a per-cell basis, memory CD8(+) T cells generated in the presence or the absence of NK cells have similar functional features and recall capabilities, NK cell deletion resulted in a significantly higher number of memory Ag-specific CD8(+) T cells, leading to more effective control of tumors carrying model Ags. The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies.
语言:: eng
DOI:: 10.4049/jimmunol.1004122

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