Immunoglobulin isoantigens (allotypes) in the mouse : V. Characterization of IgM allotypes.

Immunogenetics ·Vol. 7 ·No. 1 ·1978-12-00 ·Pages 213-30

Black SJ, Goding JW, Gutman GA, Herzenberg LA, Loken MR, Osborne BA, van der Loo W, Warner NL

Abstract

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Black S J

Department of Genetics, Stanford University School of Medicine, 94305, Stanford, California.

Goding J W

Gutman G A

Herzenberg L A

Loken M R

Osborne B A

van der Loo W

Warner N L

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Article Info

Journal

Immunogenetics

Abbr.

Immunogenetics

ISSN

0093-7711

DOI

10.1007/BF01844009

Published

1978-12-00

Pages

213-30

Language

English

Region

United States

NLM ID

0420404

External Links

PubMed source DOI: 10.1007/BF01844009 View journal details

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Immunoglobulin isoantigens (allotypes) in the mouse : V. Characterization of IgM allotypes.

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