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PMID: 21302053 Published · ppublish English Journal Article

Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system.

Immunogenetics ·Vol. 7 ·No. 1 ·1978-12-00 ·Pages 25-33

Pevzner IY, Trowbridge CL, Nordskog AW

Abstract

Evidence is presented for a crossover between the genes coding for the serologically determined (SD) antigens on erythrocytes and an immune response gene (Ir-GAT) controlling immune response to the synthetic polypeptide GAT within theB complex, the MHC of chickens. TheIr-GAT (1) andIr-GAT (19) alleles control low and high immune response to GAT, respectively. Both low and high responders were recovered as recombinants fromB (1) B (1) andB (19) B (19) birds. The low-responder haplotypes are homozygous for theIr-GAT (1) allele and the high-responder haplotypes carry theIr-GAT (19) allele. Mortality forB (1) B (1) nonresponder birds was 39%, compared with 19% for theB (1) B (1) high responders; this suggests the possibility that genes located within the immune response region of theB complex exert some genetic control over viability and survival.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pevzner I Y
Department of Animal Science, Iowa State University, 50011, Ames, Iowa.
Trowbridge C L
Nordskog A W
References (10)
10 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01843984
Published
1978-12-00
Pages
25-33
Language
English
Region
United States
NLM ID
0420404
External Links
PubMed source DOI: 10.1007/BF01843984 View journal details
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