Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice.

Immunogenetics ·Vol. 7 ·No. 1 ·1978-12-00 ·Pages 17-24

Coutinho A, Meo T

Abstract

The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F(1) hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Coutinho A

Basel Institute for Immunology, Grenzacherstrasse 487, Postfach, 4005, Basel 5, Switzerland.

Meo T

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18 references, click to expand

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Article Info

Journal

Immunogenetics

Abbr.

Immunogenetics

ISSN

0093-7711

DOI

10.1007/BF01843983

Published

1978-12-00

Pages

17-24

Language

English

Region

United States

NLM ID

0420404

External Links

PubMed source DOI: 10.1007/BF01843983 View journal details

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Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice.

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