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PMID: 21300836 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.

Antimicrobial agents and chemotherapy ·Vol. 55 ·No. 5 ·2011-05-00 ·Pages 2438-41

Baharoglu Z, Mazel D

Abstract

Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.

MeSH Terms
Aminoglycosides/pharmacology Anti-Bacterial Agents/pharmacology Chloramphenicol/pharmacology Drug Resistance, Multiple, Bacterial/genetics Fluoroquinolones/pharmacology Mutagenesis SOS Response, Genetics/drug effects Tetracycline/pharmacology Vibrio cholerae/drug effects
Chemicals
Aminoglycosides Anti-Bacterial Agents Fluoroquinolones Chloramphenicol Tetracycline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Baharoglu Zeynep
Institut Pasteur, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, 25 rue du Dr. Roux, F-75015 Paris, France.
Mazel Didier
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
1098-6596
DOI
10.1128/AAC.01549-10
Published
2011-05-00
Epub
2011-00-07
Pages
2438-41
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC3088271
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.01549-10 PMC Full Text View journal details
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