A new mechanism for blocking myeloid-derived suppressor cells by CpG.

Clinical cancer research : an official journal of the American Association for Cancer Research ·Vol. 17 ·No. 7 ·2011-04-01 ·Pages 1645-8

Lechner MG, Epstein AL

Abstract

In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.

MeSH Terms

Animals Antineoplastic Agents/pharmacology,therapeutic use DNA/pharmacology,therapeutic use Humans Immune Tolerance Immunotherapy Myeloid Cells/drug effects,immunology Neoplasms/immunology,therapy Oligodeoxyribonucleotides Toll-Like Receptor 9/agonists

Chemicals

Antineoplastic Agents CpG ODN 1826 Oligodeoxyribonucleotides Toll-Like Receptor 9 DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lechner Melissa G

Systems Biology and Disease Graduate Program, University of Southern California, Los Angeles, California, USA.

Epstein Alan L

References (18)

18 references, click to expand

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Article Info

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

Abbr.

Clin Cancer Res

ISSN

1557-3265

DOI

10.1158/1078-0432.CCR-11-0024

Published

2011-04-01

Epub

2011-00-02

Pages

1645-8

Language

English

Region

United States

NLM ID

9502500

PMCID

PMC4237605

Subset

Grants

NCI NIH HHS · P30 CA014089 · United States

Corrections

CommentOn

PMID: 21233400

External Links

PubMed source DOI: 10.1158/1078-0432.CCR-11-0024 PMC Full Text View journal details

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A new mechanism for blocking myeloid-derived suppressor cells by CpG.

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