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PMID: 2127351 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparative in vitro activities of sparfloxacin (CI-978; AT-4140) and other antimicrobial agents against staphylococci, enterococci, and respiratory tract pathogens.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 11 ·1990-11-00 ·Pages 2283-6

Simor AE, Fuller SA, Low DE

Abstract

The in vitro activity of sparfloxacin (CI-978; AT-4140) was compared with those of other antimicrobial agents against isolates of staphylococci, enterococci, and various respiratory tract pathogens. Sparfloxacin was the most active drug tested against staphylococci (MIC for 90% of the strains tested [MIC90], 0.125 micrograms/ml) and enterococci (MIC90, 1.0 microgram/ml). It was also active against Haemophilus influenzae (MIC90, less than or equal to 0.06 microgram/ml), Moraxella (Branhamella) catarrhalis (MIC90, 0.125 microgram/ml), Streptococcus pneumoniae (MIC90, 0.5 microgram/ml), and Streptococcus pyogenes (MIC90, 1.0 microgram/ml).

MeSH Terms
4-Quinolones Anti-Bacterial Agents/pharmacology Fluoroquinolones Haemophilus influenzae/drug effects Humans Microbial Sensitivity Tests Moraxella catarrhalis/drug effects Respiratory Tract Infections/microbiology Staphylococcus/drug effects Streptococcus/drug effects
Chemicals
4-Quinolones Anti-Bacterial Agents Fluoroquinolones sparfloxacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Simor A E
Department of Microbiology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
Fuller S A
Low D E
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.11.2283
Published
1990-11-00
Pages
2283-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172041
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/AAC.34.11.2283 PMC Full Text View journal details
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