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PMID: 21252623 Published · ppublish English Journal Article Review

Mitochondria removal by autophagy.

Autophagy ·Vol. 7 ·No. 3 ·2011-03-00 ·Pages 297-300

Wang K, Klionsky DJ

Abstract

Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.

MeSH Terms
Amino Acid Sequence Animals Autophagy Humans Mitochondria/metabolism Mitochondrial Proteins/chemistry,metabolism Models, Biological Molecular Sequence Data
Chemicals
Mitochondrial Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wang Ke
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Klionsky Daniel J
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Article Info
Journal
Autophagy
Abbr.
Autophagy
ISSN
1554-8635
DOI
10.4161/auto.7.3.14502
Published
2011-03-00
Pages
297-300
Language
English
Region
United States
NLM ID
101265188
PMCID
PMC3359476
Subset
IM
Grants
NIGMS NIH HHS · R01 GM053396 · United States
External Links
PubMed source DOI: 10.4161/auto.7.3.14502 PMC Full Text View journal details
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