Deactivation of persistently activated pancreatic adenylate cyclase. Evidence of uncoupling of hormone receptors and enzyme effector in the persistently activated state, and of the presence of two guanyl nucleotide regulatory sites.

Adenylyl Cyclases/metabolism Animals Cell Membrane/enzymology Cholecystokinin/pharmacology Enzyme Activation/drug effects Guanine Nucleotides/metabolism Guanylyl Imidodiphosphate/pharmacology Kinetics Pancreas/enzymology Rats Receptors, Cell Surface/metabolism Secretin/pharmacology

Guanine Nucleotides Receptors, Cell Surface Secretin Guanylyl Imidodiphosphate Cholecystokinin Adenylyl Cyclases