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题目:: Differential susceptibility of metastatic lymphoma cells to natural immunity.
作者:: Hao(W M),Joshi(S S)
状态:: 发布时间1991-01-02 , 更新时间 2008-11-21
期刊:: Oncology
摘要:: The susceptibility of metastatic variant lymphoma cells to natural immunity was studied using a low malignant/metastatic parental RAW117-P cell line and its liver colonizing highly malignant/metastatic RAW117-H10 cell line. The metastatic variant RAW117-H10 cells express a significantly lower amount of laminin-like and fibronectin-like molecules as determined by flow cytometry using monospecific polyclonal antibodies to laminin and fibronectin. Our studies indicated that the RAW117-H10 cells are resistant to natural killer (NK) cell-mediated cytotoxicity. In vitro activation of the effector cells with interferon-gamma increased the susceptibility of these cells to NK-mediated cytotoxicity while maintaining the difference between the two cell lines. However, when recombinant interleukin-2 was used to activate the effector cells, the cytotoxicity of the lymphokine-activated effector cells to both parental low metastatic RAW117-P cells and highly metastatic RAW117-H10 cells was similar.
语言:: eng
DOI:

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