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PMID: 21220943 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states.

Cell cycle (Georgetown, Tex.) ·Vol. 10 ·No. 2 ·2011-01-15 ·Pages 229-40

Komar AA, Hatzoglou M

Abstract

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has received increased attention during recent years due to its emerging significance for many physiological and pathological stress conditions in eukaryotic cells. Expression of genes bearing IRES elements in their mRNAs is controlled by multiple molecular mechanisms, with IRES-mediated translation favored under conditions when cap-dependent translation is compromised. In this review, we discuss recent advances in the field and future directions that may bring us closer to understanding the complex mechanisms that guide cellular IRES-mediated expression. We present examples in which the competitive action of IRES-transacting factors (ITAFs) plays a pivotal role in IRES-mediated translation and thereby controls cell-fate decisions leading to either pro-survival stress adaptation or cell death.

MeSH Terms
Mitosis Neovascularization, Pathologic/metabolism Protein Biosynthesis RNA, Messenger/chemistry,genetics,metabolism Regulatory Sequences, Ribonucleic Acid Signal Transduction Transcription Factors/metabolism,physiology
Chemicals
RNA, Messenger Regulatory Sequences, Ribonucleic Acid Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Komar Anton A
Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, USA. a.komar@csuohio.edu
Hatzoglou Maria
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Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.10.2.14472
Email
a.komar@csuohio.edu
Published
2011-01-15
Epub
2011-00-15
Pages
229-40
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3048795
Subset
IM
Grants
NIDDK NIH HHS · DK060596 · United States
NIDDK NIH HHS · R01 DK053307 · United States
NIDDK NIH HHS · R37 DK060596 · United States
NIDDK NIH HHS · DK053307 · United States
NIDDK NIH HHS · R01 DK060596 · United States
External Links
PubMed source DOI: 10.4161/cc.10.2.14472 PMC Full Text View journal details
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