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PMID: 21220777 Published · ppublish English Comment Letter Research Support, N.I.H., Intramural

Is microbial translocation a cause or consequence of HIV disease progression?

The Journal of infectious diseases ·Vol. 203 ·No. 5 ·2011-03-01 ·Pages 744-5; author reply 746

Redd AD, Gray RH, Quinn TC

Abstract

暂无摘要

MeSH Terms

Animals Bacterial Translocation/immunology Cross-Sectional Studies Disease Progression HIV Infections/immunology,virology HIV-1/physiology HIV-2/physiology Humans Lipopolysaccharides/blood Longitudinal Studies

Chemicals

Lipopolysaccharides

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Redd Andrew D

Gray Ronald H

Quinn Thomas C

References (15)

15 references, click to expand

Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Nat Med. 2006 Dec;12(12):1365-71 PMID: 17115046
Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection.
AIDS. 2010 Jun 19;24(10):1415-23 PMID: 20495440
Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy.
AIDS. 2010 Jun 1;24(9):1281-90 PMID: 20559035
Plasma levels of bacterial DNA in HIV infection: the limits of quantitative polymerase chain reaction.
J Infect Dis. 2010 Jul 1;202(1):176-7; author reply 178 PMID: 20518669
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.
PLoS One. 2008 Jun 25;3(6):e2516 PMID: 18575590
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
Mucosal Immunol. 2010 Jul;3(4):387-98 PMID: 20357762
Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels.
Mucosal Immunol. 2010 Mar;3(2):172-81 PMID: 19956090
Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients.
AIDS. 2009 Jan 28;23(3):369-75 PMID: 19114856
C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.
J Acquir Immune Defic Syndr. 2010 Aug;54(5):556-9 PMID: 20463585
Microbial translocation in simian immunodeficiency virus (SIV)-infected rhesus monkeys (Macaca mulatta).
J Med Primatol. 2010 Aug;39(4):243-51 PMID: 20618590
Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis.
J Clin Microbiol. 2008 Feb;46(2):757-8 PMID: 18094140
HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers.
PLoS One. 2009 May 21;4(5):e5644 PMID: 19461969
Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa.
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6718-23 PMID: 19357303
Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections.
J Infect Dis. 2010 Apr 15;201(8):1150-4 PMID: 20199244
Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy.
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Article Info

Journal

The Journal of infectious diseases

Abbr.

J Infect Dis

ISSN

1537-6613

DOI

10.1093/infdis/jiq107

Published

2011-03-01

Epub

2011-00-10

Pages

744-5; author reply 746

Language

English

Region

United States

NLM ID

0413675

PMCID

PMC3072727

Subset

Grants

Intramural NIH HHS · ZIA AI000361-29 · United States

Corrections

CommentOn

PMID: 20199244

CommentOn

PMID: 20629534

External Links

PubMed source DOI: 10.1093/infdis/jiq107 PMC Full Text View journal details

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