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PMID: 21195345 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

NF-κB, inflammation, and metabolic disease.

Cell metabolism ·Vol. 13 ·No. 1 ·2011-01-05 ·Pages 11-22

Baker RG, Hayden MS, Ghosh S

Abstract

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

MeSH Terms
Animals Humans Inflammation/genetics,physiopathology Inflammation Mediators/immunology,metabolism Macrophages/immunology,pathology Metabolic Diseases/genetics,immunology,metabolism,physiopathology NF-kappa B/antagonists & inhibitors,immunology,physiology Protein Serine-Threonine Kinases/antagonists & inhibitors,physiology
Chemicals
Inflammation Mediators NF-kappa B Protein Serine-Threonine Kinases NF-kappa B kinase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Baker Rebecca G
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Hayden Matthew S
Ghosh Sankar
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Article Info
Journal
Cell metabolism
Abbr.
Cell Metab
ISSN
1932-7420
DOI
10.1016/j.cmet.2010.12.008
Published
2011-01-05
Pages
11-22
Language
English
Region
United States
NLM ID
101233170
PMCID
PMC3040418
Subset
IM
Grants
NIAID NIH HHS · R37-AI33443 · United States
NIAID NIH HHS · R37 AI033443-17 · United States
NIAID NIH HHS · R01 AI066109-05 · United States
NIAID NIH HHS · R37 AI033443-18 · United States
NIAID NIH HHS · R01 AI068977-05 · United States
NIAID NIH HHS · R01 AI068977 · United States
NIAID NIH HHS · R01-AI068977 · United States
NIAID NIH HHS · R01 AI068977-06 · United States
NIAID NIH HHS · R01 AI068977-04 · United States
NIAID NIH HHS · R01 AI066109-04 · United States
NIAID NIH HHS · R37 AI033443 · United States
NIAID NIH HHS · R37 AI033443-19 · United States
NIAID NIH HHS · R01 AI066109-06 · United States
NIAID NIH HHS · R01 AI066109 · United States
External Links
PubMed source DOI: 10.1016/j.cmet.2010.12.008 PMC Full Text View journal details
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