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PMID: 2119143 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increased tau messenger RNA in Alzheimer's disease hippocampus.

The American journal of pathology ·Vol. 137 ·No. 3 ·1990-09-00 ·Pages 497-502

Barton AJ, Harrison PJ, Najlerahim A, Heffernan J, McDonald B, Robinson JR, Davies DC, Harrison WJ, Mitra P, Hardy JA

Abstract

The microtubule-associated protein tau is present in the pathologic hallmarks of Alzheimer's disease and its production and deposition have been implicated in the pathogenesis of the disease. We detected tau mRNA using in situ hybridization histochemistry in the hippocampus, visual cortex, and cerebellum, and compared its level in Alzheimer's disease with controls. The amount of tau mRNA also was determined as a ratio of total polyadenylated mRNA in each area. A significant and gene-specific increase in tau mRNA hybridization was found in hippocampal fields CA4 and CA3, with a similar trend in the dentate gyrus. In contrast, no change was found in the visual cortex or cerebellum in Alzheimer's disease. Increased hippocampal expression of tau mRNA also was present in cases of non-Alzheimer's dementia. Enhanced tau mRNA may be a marker of attempted plasticity involving the cytoskeleton in neuronal populations affected by various neurodegenerative disorders.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/genetics,pathology Autoradiography Blotting, Northern Hippocampus/analysis,pathology Humans Microtubule-Associated Proteins/analysis,genetics Middle Aged Nucleic Acid Hybridization RNA, Messenger/analysis tau Proteins
Chemicals
Microtubule-Associated Proteins RNA, Messenger tau Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Barton A J
Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, London, United Kingdom.
Harrison P J
Najlerahim A
Heffernan J
McDonald B
Robinson J R
Davies D C
Harrison W J
Mitra P
Hardy J A
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1990-09-00
Pages
497-502
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1877517
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source PMC Full Text View journal details
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