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PMID: 21188635 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds.

Transgenic research ·Vol. 20 ·No. 5 ·2011-10-00 ·Pages 1033-42

Henquet M, Eigenhuijsen J, Hesselink T, Spiegel H, Schreuder M, van Duijn E, Cordewener J, Depicker A, van der Krol A, Bosch D

Abstract

ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing. The presence of heterogeneous high-mannose type glycans on ER-retained therapeutic proteins is undesirable for specific therapeutic applications. Previously, we described an Arabidopsis alg3-2 glycosylation mutant in which aberrant Man(5)GlcNAc(2) mannose type N-glycans are transferred to proteins. Here we show that the alg3-2 mutation reduces the N-glycan heterogeneity on ER resident glycoproteins in seeds. We compared the properties of a scFv-Fc, with a KDEL ER retention tag (MBP10) that was expressed in seeds of wild type and alg3-2 plants. N-glycans on these antibodies from mutant seeds were predominantly of the intermediate Man(5)GlcNAc(2) compared to Man(8)GlcNAc(2) and Man(7)GlcNAc(2) isoforms on MBP10 from wild-type seeds. The presence of aberrant N-glycans on MBP10 did not seem to affect MBP10 dimerisation nor binding of MBP10 to its antigen. In alg3-2 the fraction of underglycosylated MBP10 protein forms was higher than in wild type. Interestingly, the expression of MBP10 resulted also in underglycosylation of other, endogenous glycoproteins.

MeSH Terms
Arabidopsis/genetics,metabolism Endoplasmic Reticulum/genetics,metabolism Glycosylation Maltose-Binding Proteins/genetics,immunology,metabolism Mannose/genetics,metabolism Mutation Plants, Genetically Modified/genetics,metabolism Polysaccharides/genetics,metabolism Recombinant Proteins/genetics,immunology,metabolism Seeds/genetics,metabolism Single-Chain Antibodies/biosynthesis,genetics,immunology
Chemicals
Maltose-Binding Proteins Polysaccharides Recombinant Proteins Single-Chain Antibodies Mannose
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Henquet Maurice
Business Unit Bioscience, Plant Research International BV, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6700 AA Wageningen, The Netherlands. Maurice.Henquet@wur.nl
Eigenhuijsen Jochem
Hesselink Thamara
Spiegel Holger
Schreuder Mariëlle
van Duijn Esther
Cordewener Jan
Depicker Ann
van der Krol Alexander
Bosch Dirk
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Article Info
Journal
Transgenic research
Abbr.
Transgenic Res
ISSN
1573-9368
Published
2011-10-00
Epub
2010-00-25
Pages
1033-42
Language
English
Region
Netherlands
NLM ID
9209120
PMCID
PMC3174376
Subset
IM
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