Abstract
ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing. The presence of heterogeneous high-mannose type glycans on ER-retained therapeutic proteins is undesirable for specific therapeutic applications. Previously, we described an Arabidopsis alg3-2 glycosylation mutant in which aberrant Man(5)GlcNAc(2) mannose type N-glycans are transferred to proteins. Here we show that the alg3-2 mutation reduces the N-glycan heterogeneity on ER resident glycoproteins in seeds. We compared the properties of a scFv-Fc, with a KDEL ER retention tag (MBP10) that was expressed in seeds of wild type and alg3-2 plants. N-glycans on these antibodies from mutant seeds were predominantly of the intermediate Man(5)GlcNAc(2) compared to Man(8)GlcNAc(2) and Man(7)GlcNAc(2) isoforms on MBP10 from wild-type seeds. The presence of aberrant N-glycans on MBP10 did not seem to affect MBP10 dimerisation nor binding of MBP10 to its antigen. In alg3-2 the fraction of underglycosylated MBP10 protein forms was higher than in wild type. Interestingly, the expression of MBP10 resulted also in underglycosylation of other, endogenous glycoproteins.
MeSH Terms
Arabidopsis/genetics,metabolism
Endoplasmic Reticulum/genetics,metabolism
Glycosylation
Maltose-Binding Proteins/genetics,immunology,metabolism
Mannose/genetics,metabolism
Mutation
Plants, Genetically Modified/genetics,metabolism
Polysaccharides/genetics,metabolism
Recombinant Proteins/genetics,immunology,metabolism
Seeds/genetics,metabolism
Single-Chain Antibodies/biosynthesis,genetics,immunology
Chemicals
Maltose-Binding Proteins
Polysaccharides
Recombinant Proteins
Single-Chain Antibodies
Mannose
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Henquet Maurice
Business Unit Bioscience, Plant Research International BV, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6700 AA Wageningen, The Netherlands. Maurice.Henquet@wur.nl
Eigenhuijsen Jochem
Hesselink Thamara
Spiegel Holger
Schreuder Mariëlle
van Duijn Esther
Cordewener Jan
Depicker Ann
van der Krol Alexander
Bosch Dirk
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