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题目:: The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.
作者:: Schultz(K R),Klarnet(J P),Gieni(R S),HayGlass(K T),Greenberg(P D)
状态:: 发布时间1990-10-01 , 更新时间 2007-11-14
期刊:: Science
摘要:: B cells can function as antigen-presenting cells and accessory cells for T cell responses. This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL). B cell-deficient mice exhibited significantly reduced tumor-specific CD4+ helper and CD8+ cytotoxic T cell responses after priming with FBL or a recombinant vaccinia virus containing F-MuLV antigens. Moreover, these mice had diminished T cell responses to the vaccinia viral antigens. Tumor-primed T cells transferred into B cell-deficient mice effectively eradicated disseminated FBL. Thus, B cells appear necessary for efficient priming but not expression of tumor and viral T cell immunity.
语言:: eng
DOI:

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