Home LiteratureArticle Details
PMID: 2115442 Published · ppublish English Journal Article

Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 9 ·No. 5 ·1990-05-00 ·Pages 358-60

Israelski D, Remington J

Abstract

The activity of recombinant gamma interferon (rIFN-gamma) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis. Mice received either pyrimethamine or clindamycin alone or in combination with rIFN-gamma. Significantly increased survival and/or time to death was observed in animals treated with pyrimethamine or clindamycin in combination with rIFN-gamma compared to those that received treatment with any of the agents alone.

MeSH Terms
Animals Clindamycin/therapeutic use Drug Combinations Female Interferon-gamma/therapeutic use Mice Pyrimethamine/therapeutic use Recombinant Proteins Survival Rate Time Factors Toxoplasmosis, Animal/drug therapy,mortality
Chemicals
Drug Combinations Recombinant Proteins Clindamycin Interferon-gamma Pyrimethamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Israelski D
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.
Remington J
References (10)
10 references, click to expand
  1. Effect of clindamycin on acute and chronic toxoplasmosis in mice.
    Antimicrob Agents Chemother. 1974 Jun;5(6):647-51 PMID: 15825419
  2. Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii.
    Antimicrob Agents Chemother. 1989 Jan;33(1):30-4 PMID: 2712547
  3. Treatment of toxoplasmic encephalitis with intravenous clindamycin.
    Arch Intern Med. 1988 Nov;148(11):2477-82 PMID: 3190380
  4. In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes.
    J Immunol. 1987 Apr 15;138(8):2457-62 PMID: 3104467
  5. Clindamycin in a murine model of toxoplasmic encephalitis.
    Antimicrob Agents Chemother. 1987 Apr;31(4):492-6 PMID: 3606059
  6. Effect of murine interferon gamma on murine toxoplasmosis.
    J Infect Dis. 1984 Dec;150(6):961-2 PMID: 6438249
  7. [Zidovudine efficacy and tolerance in 32 patients with cerebral toxoplasmosis in the acquired immunodeficiency syndrome].
    Presse Med. 1988 Oct 15;17(35):1813-4 PMID: 2978327
  8. Immunohistological study of the anatomic relationship of toxoplasma antigens to the inflammatory response in the brains of mice chronically infected with Toxoplasma gondii.
    Infect Immun. 1981 Mar;31(3):1184-92 PMID: 7228401
  9. In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii.
    Antimicrob Agents Chemother. 1987 Feb;31(2):346-8 PMID: 3105452
  10. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.
    Science. 1988 Apr 22;240(4851):516-8 PMID: 3128869
Article Info
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Abbr.
Eur J Clin Microbiol Infect Dis
ISSN
0934-9723
DOI
10.1007/BF01973746
Published
1990-05-00
Pages
358-60
Language
English
Region
Germany
NLM ID
8804297
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01973746 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2