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PMID: 21151202 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Lysine methylation of promoter-bound transcription factors and relevance to cancer.

Cell research ·Vol. 21 ·No. 3 ·2011-03-00 ·Pages 375-80

Stark GR, Wang Y, Lu T

Abstract

p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.

MeSH Terms
DNA/metabolism Histone-Lysine N-Methyltransferase/metabolism Humans Lysine/metabolism Methylation NF-kappa B/genetics,metabolism Neoplasms/enzymology,genetics Promoter Regions, Genetic STAT3 Transcription Factor/genetics,metabolism
Chemicals
NF-kappa B STAT3 Transcription Factor DNA Histone-Lysine N-Methyltransferase Lysine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stark George R
Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. starkg@ccf.org
Wang Yuxin
Lu Tao
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Article Info
Journal
Cell research
Abbr.
Cell Res
ISSN
1748-7838
DOI
10.1038/cr.2010.174
Email
starkg@ccf.org
Published
2011-03-00
Epub
2010-00-14
Pages
375-80
Language
English
Region
England
NLM ID
9425763
PMCID
PMC3193425
Subset
IM
Grants
NCI NIH HHS · P01 CA062220 · United States
NCI NIH HHS · P01 CA62220 · United States
External Links
PubMed source DOI: 10.1038/cr.2010.174 PMC Full Text View journal details
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