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PMID: 2114368 Published · ppublish English Journal Article

Evidence that endogenous gamma interferon is produced early in Listeria monocytogenes infection.

Infection and immunity ·Vol. 58 ·No. 7 ·1990-07-00 ·Pages 2386-8

Nakane A, Numata A, Asano M, Kohanawa M, Chen Y, Minagawa T

Abstract

It has been presumed that gamma interferon (IFN-gamma), which plays an essential role in antilisterial resistance, is produced late in Listeria monocytogenes infection. In the present study, however, IFN-gamma was detected in the bloodstreams and spleens of mice from days 1 to 4 of L. monocytogenes infection by both a double-sandwich enzyme-linked immunosorbent assay and an immunohistochemical technique, suggesting that endogenous IFN-gamma is produced early but not late in L. monocytogenes infection.

MeSH Terms
Animals Female Interferon-gamma/blood,immunology Listeria monocytogenes/immunology Listeriosis/immunology Mice Spleen/cytology,immunology Time Factors
Chemicals
Interferon-gamma
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nakane A
Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.
Numata A
Asano M
Kohanawa M
Chen Y
Minagawa T
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21 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.58.7.2386-2388.1990
Published
1990-07-00
Pages
2386-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258824
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.58.7.2386-2388.1990 PMC Full Text View journal details
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