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PMID: 211433 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase.

Nature ·Vol. 275 ·No. 5679 ·1978-10-05 ·Pages 420-3

Smith CL, Kubo M, Imamoto F

Abstract

Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in phi 80 ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalAr mutation. These results indicate that DNA gyrase is involved in transcription.

MeSH Terms
Coliphages/genetics DNA Replication/drug effects DNA-Directed RNA Polymerases/metabolism Genes, Regulator/drug effects Nalidixic Acid/pharmacology Operon/drug effects RNA, Messenger/biosynthesis Topoisomerase I Inhibitors Transcription, Genetic/drug effects Tryptophan/genetics Virus Replication/drug effects
Chemicals
RNA, Messenger Topoisomerase I Inhibitors Nalidixic Acid Tryptophan DNA-Directed RNA Polymerases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Smith C L
Kubo M
Imamoto F
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/275420a0
Published
1978-10-05
Pages
420-3
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/275420a0 View journal details
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