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PMID: 2112249 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Phospholipid in the hexagonal II phase is immunogenic: evidence for immunorecognition of nonbilayer lipid phases in vivo.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 11 ·1990-06-00 ·Pages 4112-4

Rauch J, Janoff AS

Abstract

Immunization of mice with phosphatidylethanolamine in the hexagonal II phase but not the bilayer phase resulted in the induction of anti-phospholipid antibodies. These antibodies, which were strongly reactive with phosphatidylethanolamine and crossreactive with cardiolipin, had functional lupus anticoagulant activity and were characteristic of autoantibodies common in patients with autoimmune disease. Recognition of the hexagonal II phase by the afferent limb of the immune system suggests that nonbilayer phospholipids can arise in the course of membrane remodeling and induce the autoantibodies of disease.

MeSH Terms
Animals Antibodies, Antinuclear/immunology Blood Coagulation Factors/immunology Cardiolipins/immunology Lipid Bilayers/immunology Lupus Coagulation Inhibitor Lupus Erythematosus, Systemic/immunology Mice Mice, Inbred BALB C Molecular Conformation Partial Thromboplastin Time Phospholipids/immunology
Chemicals
Antibodies, Antinuclear Blood Coagulation Factors Cardiolipins Lipid Bilayers Lupus Coagulation Inhibitor Phospholipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rauch J
Division of Rheumatology, Montreal General Hospital Research Institute, McGill University, PQ, Canada.
Janoff A S
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32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.11.4112
Published
1990-06-00
Pages
4112-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC54057
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.87.11.4112 PMC Full Text View journal details
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