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PMID: 211046 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The effect of peripheral nerve cross-union on connections of single Ia fibers to motoneurons.

Experimental brain research ·Vol. 22 ·No. 3 ·1975-03-27 ·Pages 221-34

Mendell LM, Scott JG

Abstract

The distribution of Ia terminals to alpha-motoneurons has been investigated under conditions where a) the Ia fiber innervates a foreign muscle and b) the motor axon innervates a foreign muscle. This distribution has been assessed by examining which motoneurons develop an EPSP in response to stimulation of a single Ia afferent fiber. Cross-union of the medial gastrocnemius and lateral gastrocnemius-soleus nerves has been performed in 5--8 day old kittens and the effect of this procedure on Ia connections to alpha-motoneurons has been investigated in the adult about one year later. No rearrangement of synaptic connections has been observed under these conditions. The connections from self-unioned Ia afferents and to self-unioned motoneurons are also normal. The individual EPSP's in these motoneurons with regenerated axons have normal rise times. The findings of normal Ia connections as well as normal EPSP rise times in alpha-motoneurons with regenerated motor axons indicates reversibility of the changes seen in axotomized motoneurons.

MeSH Terms
Animals Cats Membrane Potentials Motor Neurons/physiology Muscles/innervation Nerve Regeneration Peripheral Nerves/physiology Synaptic Transmission
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mendell L M
Scott J G
References (31)
31 references, click to expand
  1. Rôle of nerve-muscle contact in maintaining synaptic connections.
    Exp Brain Res. 1974;20(3):307-10 PMID: 4139036
  2. Experiments utilizing monosynaptic excitatory action on motoneurons for testing hypotheses relating to specificity of neuronal connections.
    J Neurophysiol. 1962 Jul;25:559-80 PMID: 13889051
  3. An investigation into the effect of degenerating primary afferent fibers on the monosynpatic innervation of motoneurons.
    J Neurophysiol. 1962 Jul;25:544-58 PMID: 13889052
  4. Alterations of synaptic action in chromatolysed motoneurones of the cat.
    J Physiol. 1970 Nov;210(4):823-38 PMID: 4322767
  5. Properties of fast and slow alpha motoneurones following motor reinnervation.
    J Physiol. 1974 Oct;242(1):273-88 PMID: 4436826
  6. Reflex transmission in the kitten.
    J Neurophysiol. 1962 Mar;25:263-76 PMID: 14007429
  7. The behaviour of chromatolysed motoneurones studied by intracellular recording.
    J Physiol. 1958 Aug 29;143(1):11-40 PMID: 13576457
  8. Nerve endings in mammalian muscle.
    J Physiol. 1933 Apr 13;78(1):1-53 PMID: 16994401
  9. Binocular interaction in the formation of specific intertectal neuronal connexions.
    Proc R Soc Lond B Biol Sci. 1970 Apr 7;175(1039):107-47 PMID: 4392280
  10. The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones.
    J Physiol. 1957 Jun 18;137(1):22-50 PMID: 13439582
  11. Terminals of single Ia fibers: location, density, and distribution within a pool of 300 homonymous motoneurons.
    J Neurophysiol. 1971 Jan;34(1):171-87 PMID: 5540577
  12. Effect of crossing nerves to antagonistic limb muscles in the monkey.
    Arch Neurol Psychiatry. 1947 Oct;58(4):452-73 PMID: 20269882
  13. Delayed effects of peripheral severance of afferent nerve fibres on the efficacy of their central synapses.
    J Physiol. 1959 Jan 28;145(1):204-20 PMID: 13621430
  14. Connectivity changes of Ia afferents on axotomized motoneurons.
    Brain Res. 1974 Jun 20;73(2):338-42 PMID: 4364627
  15. Electrophysiological studies on gamma motoneurones.
    Acta Physiol Scand. 1960 Sep 30;50:32-40 PMID: 13725574
  16. Specific regeneration of cutaneous fibers in the cat.
    J Neurophysiol. 1973 Jan;36(1):101-14 PMID: 4705663
  17. Isometric contractions of motor units in self-reinnervated fast and slow twitch muscles of the cat.
    J Physiol. 1974 Feb;237(1):91-102 PMID: 4822590
  18. Monosynaptic excitatory action on motoneurones regenerated to antagonistic muscles.
    J Physiol. 1960 Nov;154:68-88 PMID: 13725576
  19. Terminals of single Ia fibers: distribution within a pool of 300 homonymous motor neurons.
    Science. 1968 Apr 5;160(3823):96-8 PMID: 4296007
  20. Motor unit types of cat triceps surae muscle.
    J Physiol. 1967 Nov;193(1):141-60 PMID: 16992281
  21. SINGLE MOTOR UNITS OF MAMMALIAN MUSCLE.
    J Physiol. 1965 May;178:359-67 PMID: 14298124
  22. Competitive reinnervation of rat muscles by their own and foreign nerves.
    J Neurophysiol. 1946 Sep;9:413-8 PMID: 20997624
  23. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei.
    Brain Res. 1973 Feb 28;50(2):241-64 PMID: 4705500
  24. Nonselectivity in establishment of neuromuscular connections following nerve regeneration in the rat.
    Exp Neurol. 1961 Sep;4:262-75 PMID: 13868274
  25. The responses of the primary and secondary endings of muscle spindles with intact motor innervation during applied stretch.
    Q J Exp Physiol Cogn Med Sci. 1961 Oct;46:389-98 PMID: 13881160
  26. Displacement of synaptic terminals from regenerating motoneurons by microglial cells.
    Z Zellforsch Mikrosk Anat. 1968;85(2):145-57 PMID: 5706753
  27. Development of the brain depends on the visual environment.
    Nature. 1970 Oct 31;228(5270):477-8 PMID: 5482506
  28. Re-establishment of electrophysiologically functional entorhinal cortical input to the dentate gyrus deafferented by ipsilateral entorhinal lesions: innervation by the contralateral entorhinal cortex.
    Exp Brain Res. 1973 Nov 29;18(4):396-414 PMID: 4778785
  29. Neuroglial response to sciatic neurectomy. II. Electron microscopy.
    J Comp Neurol. 1973 Oct 1;151(3):255-80 PMID: 4744474
  30. Quantitative electron microscopy on the injured hypoglossal nucleus in the rat.
    J Neurocytol. 1973 Sep;2(3):315-28 PMID: 9224494
  31. ELECTROPHYSIOLOGY OF THE FETAL SPINAL CORD. I. ACTION POTENTIALS OF THE MOTONEURON.
    J Gen Physiol. 1964 May;47:1003-22 PMID: 14155428
Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00234765
Published
1975-03-27
Pages
221-34
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00234765 View journal details
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