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题目:: Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations.
作者:: Metcalfe(Kelly),Lubinski(Jan),Lynch(Henry T),Ghadirian(Parviz),Foulkes(William D),Kim-Sing(Charmaine),Neuhausen(Susan),Tung(Nadine),Rosen(Barry),Gronwald(Jacek),Ainsworth(Peter),Sweet(Kevin),Eisen(Andrea),Sun(Ping),Narod(Steven A),
状态:: 发布时间2010-12-16 , 更新时间 2010-12-16
期刊:: J Natl Cancer Inst
摘要:: Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of breast and ovarian cancers. However, the influence of a family history of these cancers on these risks in women with BRCA mutations is unclear. We calculated cancer incidence rates for a multinational cohort comprising 3011 women with BRCA1 or BRCA2 mutations who were followed up for a mean of 3.9 years, during which time 243 incident breast or ovarian cancers were recorded. The 10-year cumulative risks of breast cancer were 18.1% (95% confidence interval [CI] = 13.3% to 22.8%) for women with a BRCA1 mutation and 15.2% (95% CI = 9.1% to 21.2%) for women with a BRCA2 mutation. Among women with a BRCA1 mutation, the risk of breast cancer increased by 1.2-fold for each first-degree relative with breast cancer before age 50 years (hazard ratio [HR] = 1.21; 95% confidence interval [CI] = 0.94 to 1.57) and the risk of ovarian cancer increased by 1.6 fold for each first- or second-degree relative with ovarian cancer (HR = 1.61; 95% CI = 1.21 to 2.14). Among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative younger than 50 years with breast cancer (HR = 1.67; 95% CI = 1.04 to 2.07).
语言:: eng
DOI:: 10.1093/jnci/djq443

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