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PMID: 21068149 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The roles of RNA in the synthesis of protein.

Cold Spring Harbor perspectives in biology ·Vol. 3 ·No. 11 ·2011-11-01 ·Pages a003780

Moore PB, Steitz TA

Abstract

The crystal structures of ribosomes that have been obtained since 2000 have transformed our understanding of protein synthesis. In addition to proving that RNA is responsible for catalyzing peptide bond formation, these structures have provided important insights into the mechanistic details of how the ribosome functions. This review emphasizes what has been learned about the mechanism of peptide bond formation, the antibiotics that inhibit ribosome function, and the fidelity of decoding.

MeSH Terms
Anti-Bacterial Agents/pharmacology Binding Sites Crystallography, X-Ray Models, Molecular Peptidyl Transferases/antagonists & inhibitors,physiology Protein Biosynthesis/genetics RNA/chemistry,physiology RNA, Ribosomal/chemistry,physiology RNA, Transfer/chemistry,metabolism Ribosomes/chemistry,physiology
Chemicals
Anti-Bacterial Agents RNA, Ribosomal RNA RNA, Transfer Peptidyl Transferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moore Peter B
Department of Molecular Biophysics, Yale University, New Haven, Connecticut 208114, USA. peter.moore@yale.edu
Steitz Thomas A
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a003780
Email
peter.moore@yale.edu
Published
2011-11-01
Epub
2011-00-01
Pages
a003780
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3220363
Subset
IM
Grants
NIGMS NIH HHS · P01 GM022778 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM022778 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a003780 PMC Full Text View journal details
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