Trisodium phosphonoformate, a new antiviral compound.

Science (New York, N.Y.) ·Vol. 201 ·No. 4358 ·1978-09-01 ·Pages 819-21

Helgstrand E, Eriksson B, Johansson NG, Lannerö B, Larsson A, Misiorny A, Norén JO, Sjöberg B, Stenberg K, Stening G, Stridh S, Oberg B

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.

MeSH Terms

Animals Antiviral Agents/therapeutic use,toxicity Cell Line DNA-Directed RNA Polymerases/antagonists & inhibitors Formates/pharmacology,toxicity Guinea Pigs Herpesviridae Infections/drug therapy Nucleic Acid Synthesis Inhibitors Organophosphorus Compounds/pharmacology,toxicity Phosphonoacetic Acid/pharmacology Simplexvirus/enzymology

Chemicals

Antiviral Agents Formates Nucleic Acid Synthesis Inhibitors Organophosphorus Compounds DNA-Directed RNA Polymerases Phosphonoacetic Acid

Authors & Affiliations

12 authors, click to expand affiliations / ORCID

Helgstrand E

Eriksson B

Johansson N G

Lannerö B

Larsson A

Misiorny A

Norén J O

Sjöberg B

Stenberg K

Stening G

Stridh S

Oberg B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.210500

Published

1978-09-01

Pages

819-21

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.210500 View journal details

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