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题目:: Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.
作者:: Yamanegi(Koji),Yamane(Junko),Kobayashi(Kenta),Kato-Kogoe(Nahoko),Ohyama(Hideki),Nakasho(Keiji),Yamada(Naoko),Hata(Masaki),Nishioka(Toshihiro),Fukunaga(Satoru),Futani(Hiroyuki),Okamura(Haruki),Terada(Nobuyuki)
状态:: 发布时间2010-11-02 , 更新时间 2013-11-21
期刊:: Oncol Rep
摘要:: MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage of cell-surface MIC interferes with NK cell-mediated cytotoxicity. We investigated effect of sodium valproate (VPA), a histone deacetylase inhibitor, on the production of cell-surface and soluble MICA and B and NK cell-mediated cytotoxicity in four human osteosarcoma cells. VPA at 0.5 and 1.0 mM induced acetylation of histones bound to MICA and B gene promoters, increased cell-surface but not soluble MICA and B, and augmented the susceptibility of osteosarcoma cells to NK cell-mediated cytotoxicity. The present results indicate that VPA sensitizes human osteosarcoma cells to cytotoxicity of NK cells.
语言:: eng
DOI:

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