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题目:: [The transcript expression of PKC-β₁ gene in human lung cancer].
作者:: Zhou(Q),Liu(L),Li(L),Wang(Y),Chen(J),Yang(J)
状态:: 发布时间2010-10-28 , 更新时间 2010-10-28
期刊:: Zhongguo Fei Ai Za Zhi
摘要:: To determine the relationship between the transcript expression of PKC-β₁ gene and pathophysilogical characteristics of lung cancer.,The expression of PKC-β₁ mRNA was detected in 50 human lung cancer tissues,para-cancerous tissues,non-cancerous tissues and 30 benign pulmonary lession tissues by Northern blot.,(1) The expression level of PKC-β₁ mRNA in lung cancer tissues was significantly higher than that in para-cancerous tissues,non-cancerous tissues and benign pulmonary lession tissues (P<0.01).(2) The expression level of PKC-β₁ in poor-differentiated cancer was significantly higher than that in moderate-well differentiated cancer (P<0.05).(3) The expression of PKC-β₁ mRNA in stage III cancer was remarkably higher than that in stage I and stage II disease (P<0.01).(4) The expression of PKC-β₁ in cancer with lymph node metastasis was significantly higher than that in the cancer without lymph node involvement (P<0.01).,There is an overexpression of PKC-β₁ mRNA in lung cancer tissues,and it may play an important role in the advancement,cancer cell differentiation and metastasis of lung cancer.
语言:: chi
DOI:: 10.3779/j.issn.1009-3419.2000.05.10

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