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题目:: Maturation of tumor vasculature by interferon-beta disrupts the vascular niche of glioma stem cells.
作者:: Williams(R F),Sims(T L),Tracey(L),Myers(A L),Ng(C Y C),Poppleton(H),Nathwani(A C),Davidoff(A M)
状态:: 发布时间2010-10-14 , 更新时间 2010-10-14
期刊:: Anticancer Res
摘要:: The vascular niche necessary for cancer stem cell maintenance is a potential target for cancer therapy.,Human glioma xenografts were treated with IFN-β delivered systemically via a liver-targeted, adeno-associated viral vector. The vascular niche was examined with immunofluorescence for glioma stem cells, endothelial cells, and perivascular cells.,Although IFN-β was not directly toxic to glioma stem cells in vitro, IFN-β decreased tumor size and the number of stem cells recovered in both heterotopic and orthotopic models. Treatment with IFN-β increased perivascular cells investing the tumor vasculature (6-fold) distancing stem cells from endothelial cells. Additionally, vascular smooth muscle cells co-cultured between stem cells and endothelial cells decreased stem cell recovery.,Continuous delivery of IFN-β decreased the number of stem cells in glioma xenografts by disrupting the vascular niche through an increase in perivascular cells, which created a barrier between the glioma stem cells and the endothelial cells.
语言:: eng
DOI:

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