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PMID: 20876796 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Portable filter-based microdevice for detection and characterization of circulating tumor cells.

Lin HK, Zheng S, Williams AJ, Balic M, Groshen S, Scher HI, Fleisher M, Stadler W, Datar RH, Tai YC, Cote RJ

Abstract

Sensitive detection and characterization of circulating tumor cells (CTC) could revolutionize the approach to patients with early-stage and metastatic cancer. The current methodologies have significant limitations, including limited capture efficiency and ability to characterize captured cells. Here, we report the development of a novel parylene membrane filter-based portable microdevice for size-based isolation with high recovery rate and direct on-chip characterization of captured CTC from human peripheral blood. We evaluated the sensitivity and efficiency of CTC capture in a model system using blood samples from healthy donors spiked with tumor cell lines. Fifty-nine model system samples were tested to determine the recovery rate of the microdevice. Moreover, 10 model system samples and 57 blood samples from cancer patients were subjected to both membrane microfilter device and CellSearch platform enumeration for direct comparison. Using the model system, the microdevice achieved >90% recovery with probability of 95% recovering at least one cell when five are seeded in 7.5 mL of blood. CTCs were identified in 51 of 57 patients using the microdevice, compared with only 26 patients with the CellSearch method. When CTCs were detected by both methods, greater numbers were recovered by the microfilter device in all but five patients. This filter-based microdevice is both a capture and analysis platform, capable of multiplexed imaging and genetic analysis. The microdevice presented here has the potential to enable routine CTC analysis in the clinical setting for the effective management of cancer patients.

MeSH Terms
Cell Line, Tumor Dimethylpolysiloxanes Hemofiltration/instrumentation Humans Membranes, Artificial Microfluidic Analytical Techniques/instrumentation Neoplasms/blood,pathology Neoplastic Cells, Circulating/pathology Polymers Xylenes
Chemicals
Dimethylpolysiloxanes Membranes, Artificial Polymers Xylenes parylene baysilon
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Lin Henry K
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Zheng Siyang
Williams Anthony J
Balic Marija
Groshen Susan
Scher Howard I
Fleisher Martin
Stadler Walter
Datar Ram H
Tai Yu-Chong
Cote Richard J
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Article Info
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Abbr.
Clin Cancer Res
ISSN
1557-3265
Published
2010-10-15
Epub
2010-00-28
Pages
5011-8
Language
English
Region
United States
NLM ID
9502500
PMCID
PMC2955786
Subset
IM
Grants
NCI NIH HHS · R01 CA141077 · United States
NEI NIH HHS · P30 EY003040 · United States
NEI NIH HHS · EY03040 · United States
NCI NIH HHS · R21 CA123027 · United States
NCI NIH HHS · R33 CA123027 · United States
NCI NIH HHS · 1R21CA123027 · United States
Corrections
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